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East Central Indiana



Medications Information: Drysol

Hyperhidrosis is a medical term for excessive sweating. The problem may be limited to the armpits, but often the palms and soles also sweat excessively. Excessive sweating becomes noticeable after puberty. Stressful situations such as examinations, job interviews, or an important date might aggravate the sweating. Unfortunately, most over-the-counter antiperspirants do not control the problem.  Prescription treatment aims to control excessive sweating. It is not a permanent cure. The prescription we use is called DRYSOL which is a 20% aluminum chloride hexahydrate alcohol solution. It is important that you understand how to use the medicine in order to get the best effect.


Apply the medicine at bedtime to your dry armpits. To prevent irritation, wash it off in the morning with plain water. Do not use your regular daytime deodorant. Repeat the treatment nightly until the sweating is under control. The treatment may then be decreased to every other night. If the perspiration is controlled, the application may be reduced to every third night or less frequently as needed to control excessive perspiration. Most people can control excessive armpit sweating by overnight applications.

Sometimes it is necessary to increase the medicine's penetration by covering with a plastic film overnight. After applying the Drysol to your armpits at night, cover them with a pliable plastic wrap, such as Saran wrap. Keep the plastic wrap in place with a t-shirt or similar light garment. Do not use tape. In the morning, remove the plastic film and gently wash your armpits with plain water. Drysol may irritate your skin. If your armpits become sore or itchy, please contact the office.  Until your excessive armpit sweating is controlled, apply only the Drysol and water to your armpits.  Later, when the sweating is under control, you may try your daytime deodorant.

Palms and soles

The thick skin of the palms and soles is more resistant to the aluminum chloride effect. At first, apply the medicine at bedtime to your dry palms and soles, and in the morning wash it off with plain water. If in ten to fourteen days you do not see a decrease in sweating, cover your hands and feet overnight with a plastic film. For your hands, use the thin pliable plastic disposable gloves available in most drug stores. After applying the medicine, allow it to dry, and then put on the plastic gloves. Remove the gloves in the morning and wash your hands with plain water.

For the feet, use plastic bags held in place with socks. Cut the plastic to size so that they cover only your feet and not your legs. In the morning, remove the plastic bags and wash your feet with plain water. Repeat the Drysol application and plastic covering nightly for one to two weeks until you get the desired effect, then do it less often. 

Usually local applications of Drysol provide satisfactory sweat control. If they fail, we can work with you on alternative treatment methods. Please do not hesitate to contact the office if treatment control is a problem.